Spouses Adrian and Natalia lived in the city of Nicomedia in the Bithynian region of Asia Minor. Hadrian was a pagan and served as an official of Emperor Maximian Galerius (305-311), the persecutor of Christians. Natalia was a secret Christian. During the persecution near Nicomedia, 23 believers hid in a cave. They were caught, tried, tortured, and forced to sacrifice to idols. Then they were taken to the court chamber to write down their names. Adrian, the head of the ward, was here, who asked them what reward they expected from their God for their torments. 
They answered him, "The eye has not seen it, the ear has not heard it, and it has not entered into the heart of man, what God has prepared for those who love him" (1 Corinthians 2:9). When Adrian heard this, he said to the scribes, "Write down my name with them, because I am a Christian." Adrian was put in jail. The emperor advised him to delete his name from the list of Christians and ask for forgiveness. Adrian assured him that he had not gone mad, but had acted on his own conviction. He turned 28 years old then.
After learning about the incident, Natalia rushed to prison, where she encouraged Adrian to be courageous. When the Christian prisoners were sentenced to death, Adrian was allowed to go home for a short time so that he would inform his wife about this. When Natalia saw Adrian, she was afraid that he had renounced Christ, and did not let him into the house.
Returning to prison, Adrian, along with other martyrs, was subjected to terrible tortures: the martyrs had their arms and legs broken with a heavy hammer, from which they died in terrible agony. When Adrian's turn came, the wife was most afraid that her husband would not be cowardly and deny Christ. She strengthened Adrian and held his arms and legs while the executioner killed them with a hammer. Saint Adrian died along with the rest of the martyrs in 304. When their bodies began to be burned, a thunderstorm arose and the furnace went out, and several executioners were killed by lightning.
The commander of the army wanted to marry Natalia, who was still young and rich. Even before Adrian's death, Natalia asked him to pray that she would not be forced to marry. Now Adrian appeared to her in a dream and told her that she would soon follow him. And so it happened: Natalia died on her husband's coffin on the outskirts of the city of Byzantium, where his body was transferred by believers.